Overly reactivated star-shaped cells explain the unpredictability of Alzheimer’s disease

Though Alzheimer’s disease (AD) is a common and fatal neurodegenerative brain disorder, most AD treatments are not making much headway in adressing its cause. Many AD drugs have targeted the elimination of beta-amyloid (Aβ) or amyloid plaques, which block cell-to-cell signaling at synapses. But some AD patients continue to show neurodegeneration and cognitive decline even […]

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Cynical hostility presents a potential pathway to cardiovascular disease

Cynical hostility is a potential pathway to cardiovascular disease by preventing a healthy response to stress over time, according to a study led by Baylor University. Hostility generally is associated with increased risk for cardiovascular disease. But this research explored three types of hostility—emotional, behavioral and cognitive—to see whether one is more predictive of risk […]

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Low levels of choline in pregnant Black American women associated with higher levels of stress

Researchers at the University of Colorado Anschutz Medical Campus have found that many pregnant Black Americans have low levels of choline, an essential nutrient that aids in prenatal brain development. Stress caused by institutional racism may play a role. The study, out now in Schizophrenia Bulletin, also found that these low levels of choline were […]

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Chronic alcohol use reshapes the brain’s immune landscape, driving anxiety and addiction

Deep within the brain, a small almond-shaped region called the amygdala plays a vital role in how we exhibit emotion, behavior and motivation. Understandably, it’s also strongly implicated in alcohol abuse, making it a long-running focus of Marisa Roberto, Ph.D., professor in Scripps Research’s Department of Molecular Medicine. Now, for the first time, Roberto and […]

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